Ivermectin’s Anticancer Role: Uses, Mechanism, Dosage &; Cancer Protocols

Cancer disease is a pandemic today with an exponential increase in the burden on the healthcare communities globally. The development of the tumor cells can take place in any region of the patient’s body like the breast, blood, colon, lungs, and other areas. In the year 2023 alone, there were more than 1.6 million of cases of the different forms of cancer as per the report from CDC, United States.

For a long, conventional therapeutic approaches have been utilized for example chemotherapy, Radiation therapy, and surgical interventions. And there are significant advances that have been made in the treatment of cancer that include targeted, stem cell procedures, natural antioxidants, chemo dynamic, and others. However, conventional treatments lead to several of side effects that are long-lasting. Owing to this, many of the patients are turning towards alternative/ complementary therapeutic procedures for elevating the side effects.

Ivermectin multipurpose drug for parasitic infections & cancer treatment

Looking at the dire need of a therapeutic strategy for cancer cure, Ivermectin a chief veterinary drug, has been repurposed for the treatment of different cancer categories like leukemia, breast cancer, ovarian, glioma as well as colon cancers.
This repurposed antiparasitic drug has been found to induce apoptosis, within the carcinomas. Also, this antiparasitic remedy is found to conduct the inhibition of proliferation of the tumor cells, metastasis along with angiogenesis in different carcinomas.

In this blog post, let’s dive deep into the uses, work mechanisms, and ivermectin dosages and protocols for treating different types of cancers.

What is Ivermectin brief overview

What is Ivermectin: brief overview?

With its introduction in the 1970s, Ivermectin, a derivative of avermectin since long is a versatile Pharmaceutical therapy, originally formulated for treating parasitic infections.
However, today emerging research studies indicate that the role of this human and animal cure product goes beyond assisting out in treating inflammatory conditions, infections due to viruses, and different forms of cancers, for example, brain cancer, bladder, bowel cancer, breast cancer, leukaemia, lymphoma prostate cancer, tumor in the lungs, colorectal carcinoma and others.

Ivermectin uses: from antiparasitic to anticancer effects

Widely produced and prescribed for the treatment of parasitic infections, with approval of the World Health Organization, WHO, ivermectin since has long been utilized for treating infections taking place through the worms, lice within the head, scabies, and others.
The drug also possesses growth-inhibitory impact on the carcinoma cells. And this is actually with the initiation of the dysfunction off the mitochondrial as well as the oxidative damages.

Work mechanism of ivermectin for cancer cure

The antiparasitic drug carry out the proliferation as well as the metastasis of the carcinoma, leading to the mortality of the cells.
The Ivermectin demonstrates the extraordinary benefits against the conventional chemotherapy, carcinoma cells that are drug resistant as well as converging multi-drug resistivity.
The structuring of the cross-talk positioning on the PAK 1 Kinase, is demonstrates the mechanism in which ivermectin is regulating the multiple of pathways of signaling.

Ivermectin availability in different forms as well as strengths:

Tablet- 3mg, 6 mg & 12 mg
Lotion-0.5%
Cream- 1%

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Ivermectin dosage and protocol for different parasitic infections in adults

Parasitic infection type	Standardized dosage & protocol
Strongyloidiasis	0.2 mg/ Kg for administration of single dose
Onchocerciasis	0.5 mg/Kg for administration of single dosage
Scabies	0.2 mg/Kg in the tablet formula for two dosages every 15 days
Pediculosis Capitis	0.2 mg/Kg in the tablet formulation after every 10 days
Pediculosis pubis	0.2 mg/Kg in the tablet formulation after every 1-2 Weeks For two dosages
Rosacea inflammatory lesions	1% cream applicable on daily basis to the Affected part

Ivermectin protocol & dosage for curing different cancer categories

Cancer Category	Ivermectin dosage & protocol
Ovarian Cancer	12 mg IVM per day for two months
Brain Cancer	1-2 mg/ Kg/day
Breast Cancer	2 mg/Kg/ day
Spine Cancer	0.5 mg/Kg/ day
Prostate Cancer	45 mg Of Ivermectin per day for two months
Lung Cancer	12 mg Ivermectin per day for 3 months
Colon & Liver cancer	24 mg of Ivermectin twice a day
Cervical cancer	12 mg IVM per day for 2 weeks